James S. McDonnell Foundation - Legacy Program

Researching Brain Cancer (n=93)

Albert Einstein College of Medicine of Yeshiva University Jean M. Hébert, Ph.D. Genetic lesions in the BMP pathway as a mechanism underlying brain tumors https://doi.org/10.37717/220020076	2005 $298,977 USA
Bar-Ilan University Chaya Brodie, Ph.D. Molecular Mechanisms of PKC Functions in the Growth and Apoptosis of Glioma Cells https://doi.org/10.37717/20002061	2000 $445,000 Israel
Baylor College of Medicine Mostafa W. Gaber, Ph.D. Identifying preclinical imaging markers of radiation side effects: An animal brain tumor model to correlate radiation-induced imaging changes, neurogenesis and cognitive impairment https://doi.org/10.37717/220020250	2010 $450,000 USA
Baylor College of Medicine Stephen Gottschalk, M.D. Improving EphA2-targeted T-cell Therapy for Glioma https://doi.org/10.37717/220020317	2012 $450,000 USA
Baylor College of Medicine John Y. Kim WIP1 in medulloblastoma growth and genotoxic response	2005 $449,385 USA
Cedars-Sinai Medical Center Daniel R. Scoles, Ph.D. Regulation of protein translation by the NF2 tumor suppressor schwannomin	2003 $150,000 USA
Cedars-Sinai Medical Center Daniel R. Scoles, Ph.D. Regulation of protein translation by the NF2 tumor suppressor schwannomin	2004 $300,000 USA
Children's Medical Research Institute Megan Chircop, Ph.D. Dynamin as a new drug target for the treatment of glioblastoma https://doi.org/10.37717/220020204	2009 $164,000 Australia
City of Hope National Medical Center and Beckman Research Institute Behnam Badie, M.D. Role of Receptor for Advanced Glycation End product (RAGE) pathway in brain tumor macrophage function https://doi.org/10.37717/220020179	2008 $450,000 USA
City of Hope National Medical Center and Beckman Research Institute Yanhong Shi, Ph.D. Nuclear receptor TLX and its targeting microRNAs inbrain tumor stem cells https://doi.org/10.37717/220020143	2007 $112,500 USA
Cleveland Clinic Jeremy N. Rich, M.D. Microenvironmental Reprogramming of Glioma Cells https://doi.org/10.37717/220020201	2009 $450,000 USA
Cleveland Clinic Foundation Gregory Plautz, M.D. Co-P.I.s: Suyu Shu, Jorgen Kjaergaard, Takashi Hayashi Effector Mechanisms of T Cell Immunotherapy of Brain Tumors https://doi.org/10.37717/9900001	1999 $375,000 USA
Columbia University Andrew Lassman, M.D. Phase II Clinical Trial of Perifosine + Temsirolimus for Recurrent Glioblastoma with Tissue and Imaging Correlates of Response https://doi.org/10.37717/220020320	2012 $449,148 USA
Columbus Children's Research Institute Jiayuh Lin, Ph.D. STAT3 as a novel therapeutic target for glioblastoma multiforme https://doi.org/10.37717/220020135	2007 $120,000 USA
Dana-Farber Cancer Institute Lynda Chin, M.D. Understanding the molecular basis of therapeutic resistance in GBM https://doi.org/10.37717/220020037	2003 $450,000 USA
Dana-Farber Cancer Institute Howard A. Fine, M.D. Endothelial Cell Mediated Therapeutic Gene Transfer	1998 $449,879 USA
Dana-Farber Cancer Institute David H. Rowitch, M.D., Ph.D. Cell cycle regulation during CNS development by hedgehog signaling and proto-oncogene in n-myc https://doi.org/10.37717/21002062	2002 $450,000 USA
Dana-Farber Cancer Institute Rosalind A. Segal, M.D., Ph.D. Genetic Modifiers of Medulloblastoma https://doi.org/10.37717/20002065	2000 $450,000 USA
Duke University Hai Yan, M.D., Ph.D. Role of IDH1/2 mutations in cell metabolism, differentiation and gliomagenesis	2011 $450,000 USA
Duke University Medical Center Robert Wechsler-Reya, Ph.D. Molecular evolution of a brain tumor: Analysis of pre-tumor cells in a mouse model of medulloblastoma https://doi.org/10.37717/21002064	2002 $416,559 USA
Emory University School of Medicine Erwin G. Van Meir, Ph.D. This grant awarded under The Brain Tumor Funders' Collaborative (BTFC) 2009 RFP. Development of Protein Arrays for the Detection of Biomarkers in the CSF of Brain Tumor Patients	2009 $100,000 USA
German Cancer Research Center Stefan Pfister, M.D. Use of cerebrospinal fluid genetics for the diagnosis, subgrouping, and minimal residual disease monitoring in medulloblastoma (update March 2012)	2012 $441,462 Germany
German Cancer Research Center Stefan Pfister, M.D. Dr. Pfister is also affiliated with Heidelberg University Hospital Use of cerebrospinal fluid genetics for the diagnosis, subgrouping, and minimal residual disease monitoring in medulloblastoma	2011 $159,390 Germany
Gray Cancer Institute - Mount Vernon Hospital Susan C. Short, Ph.D. Investigation of non-targeted effects of radiation in gliomas and normal brain cells https://doi.org/10.37717/21002067	2002 $281,979 United Kingdom
Henry Ford Hospital Sandra A. Rempel, Ph.D. Characterization of the SPARC-Induced Changes in Glioblastoma Adhesion, Migration, and Signaling Pathways	1998 $227,709 USA
Hugo W. Moser Research Institute at Kennedy Krieger John J. Laterra, M.D., Ph.D. This grant awarded under The Brain Tumor Funders' Collaborative (BTFC) 2005 RFP. Tumor Stem Cell-Based Drug Discovery for Adult and Pediatric Glioma	2006 USA
Hugo W. Moser Research Institute at Kennedy Krieger John J. Laterra, M.D., Ph.D. Regulatory mechanisms and therapeutic targeting of brain cancer "Stem Cells"	2009 USA
Institute for Systems Biology Leroy Hood, M.D., Ph.D. Secreted molecular fingerprints for glioma diagnosis and a novel approach for In-Vivo identification of disease-causing network perturbations https://doi.org/10.37717/220020108	2006 $150,000 USA
Johns Hopkins University Alena Horská, Ph.D. This grant awarded under The Brain Tumor Funders' Collaborative (BTFC) 2009 RFP. Non-invasive Assessment of Glutamate in Glioblastoma Multiforme: Effect of Treatment	2009 $100,000 USA
Johns Hopkins University Gary Pasternack, Ph.D. Induced Differentiation of Medulloblastoma	2002 $30,000 USA
Johns Hopkins University School of Medicine Gary R. Pasternack, M.D., Ph.D. Induced differentiation of medulloblastoma	2002 $150,000 USA
Ludwig Institute for Cancer Research Ltd Frank Furnari, Ph.D. EGFR inhibitor resistance in glioblastoma: deciphering the role of FGFR-mediated PTEN phosphorylation https://doi.org/10.37717/220020319	2012 $446,844 USA
Massachusetts General Hospital Khalid Shah, Ph.D. Evaluating novel stem cell based therapies for brain tumors https://doi.org/10.37717/220020245	2010 $450,000 USA
Massachusetts General Hospital Tomoki Todo, M.D., Ph.D. Brain Tumor Therapy with Replication-Competent Virus Vectors Expressing Secretory Fusion Proteins	2000 $450,000 USA
Massachusetts General Hospital-Molecular Neuro-Oncology Laboratory Catherine L. Nutt, Ph.D. Molecular profile-based investigation of chemosensitive anaplastic oligodendrogliomas https://doi.org/10.37717/220020086	2005 $300,000 USA
Massachusetts Institute of Technology Forest M. White, Ph.D. Integrative systems-level approach to glioblastoma targeted therapy	2009 $240,000 USA
Memorial Sloan-Kettering Cancer Center Ingo K. Mellinghoff, M.D. Genotype focused EGFR targeting in glioblastoma	2011 $450,000 USA
Monash Institute of Medical Research Terrance G. Johns, Ph.D. Establishing efficacious combinations of targeted therapies for the treatment of glioma https://doi.org/10.37717/220020173	2008 $386,500 Australia
National University of Cordoba (Universidad Nacional de Córdoba) Beatriz L. Caputto, Ph.D. Cellular transformation by c-FOS: A nuclear and cytoplasmic event? https://doi.org/10.37717/21002065	2002 $300,000 Argentina
New York University Elizabeth W. Newcomb, Ph.D. Experimental Mouse Glioma to Study Novel Inhibitors of Tumor Growth https://doi.org/10.37717/20002062	2000 $300,000 USA
Northwestern University John A. Kessler, M.D. A New Approach to the Treatment of Brain Tumors https://doi.org/10.37717/220020205	2009 $146,969 USA
Northwestern University Alexander Stegh, Ph.D. The Bcl2L12-microRNA-182 axis in glioblastoma https://doi.org/10.37717/220020295	2011 $450,000 USA
Northwestern University Jane Y. Wu, M.D., Ph.D. Designing new therapy by blocking brain tumor invasion and metastasis https://doi.org/10.37717/220020180	2008 $450,000 USA
Purdue University R. Graham Cooks, Ph.D. Intrasurgical molecular diagnosis of human brain gliomas by mass spectrometry imaging https://doi.org/10.37717/220020299	2011 $125,472 USA
St. Jude Children's Research Hospital Martine F. Roussel, Ph.D. Small molecule BMP agonists as therapeutic agents for brain tumors https://doi.org/10.37717/220020247	2010 $150,000 USA
Stanford University J. Martin Brown, Ph.D. Increasing the radiocurability of GBM by inhibition of tumor vasculogenesis https://doi.org/10.37717/220020136	2007 $122,607 USA
Stanford University Lawrence D. Recht, M.D. Characterization of a glioma precursor lesion https://doi.org/10.37717/220020103	2006 $150,000 USA
Stanford University Matthew P. Scott, Ph.D. Regulation of medulloblastoma by the sterol synthesis pathway https://doi.org/10.37717/220020133	2007 $450,000 USA
Technion, Israel Institute of Technology Gera Neufeld, Ph.D. The effects of Class-3 semaphorins on the development and progression of brain tumors https://doi.org/10.37717/220020149	2007 $350,000 Israel
Tel Aviv Sourasky Medical Center Dafna Ben Bashat, Ph.D. Advanced dynamic vascular imaging for high-grade gliomas https://doi.org/10.37717/220020176	2008 $418,400 Israel
The Hebrew University of Jerusalem Alexander Levitzki The Inhibition of Anti-Apoptotic Pathways in Brain Glioma	1998 $398,700 Israel
The University of Melbourne David M. Ashley Investigation of Resistance to the Biological Mediators of Apoptosis Conferred by Expression of the Type III Mutant Epidermal	1998 $411,897 Australia
Universidad Nacional de Cordoba Caputto Beatriz, Ph.D. Cellular Transformation By c-FOS: A Nuclear and A Cytoplasmic Event?	2002 $30,000 Spain
Universidad Nacional de Cordoba Caputto Beatriz, Ph.D. In support of an international workshop on brain cancer research "Tango Lesson for Brain Cancer Research-Understanding Cellular Intricacy, Improvising New Therapies"	2006 $60,000 Spain
University of California - Berkeley Michael R. DeWeese, Ph.D. To establish contacts for preliminary studies testing the idea of using visual sparse coding information to interpret brain cancer MR images	2010 $50,000 USA
University of California - Davis Elva D. Diaz, Ph.D. Molecular mechanisms of cerebellar granule cell proliferation and medulloblastoma	2006 $360,000 USA
University of California - Davis Elva D. Diaz, Ph.D. Molecular mechanisms of cerebellar granule cell proliferation and medulloblastoma	2005 $90,000 USA
University of California - Los Angeles Hong Wu, M.D., Ph.D. The role of the tumor suppressor gene PTEN in neural stem cell biology and brain tumor development https://doi.org/10.37717/220020038	2003 $150,000 USA
University of California - Los Angeles Children's Hospital Stanley F. Nelson, M.D. Creation of Glioma-Related cDNA Microarray	1998 $450,000 USA
University of California - San Diego Santosh Kesari, Ph.D., M.D. Mechanisms of Sensitivity to PDGFR Inhibitors in Human Gliomas https://doi.org/10.37717/220020202	2009 $424,476 USA
University of California - San Francisco Manish K. Aghi, M.D., Ph.D. Identifying and overcoming glioblastoma resistance to treatments targeting vascular endothelial growth factor https://doi.org/10.37717/220020178	2008 $449,690 USA
University of California - San Francisco Joseph F. Costello, Ph.D. Using aberrant methylation patterns for tumor classification and prediction of malignant progression https://doi.org/10.37717/20002060	2000 $445,356 USA
University of California - San Francisco C. David James, Ph.D. BRAF-driven pediatric malignant astrocytoma: Etiology & treatment https://doi.org/10.37717/220020243	2010 $450,000 USA
University of California - San Francisco Joanna Phillips, M.D., Ph.D. Proteoglycans as novel biomarkers and therapeutic targets in glioblastoma https://doi.org/10.37717/220020316	2012 $450,000 USA
University of Florida Wolfgang J. Streit, Ph.D. Glioblastoma and the Brain's Immune System https://doi.org/10.37717/21002025	2001 $449,998 USA
University of Florida Sean M. Sullivan, Ph.D. Development of Gene Delivery Systems for the Treatment of Brain Cancer https://doi.org/10.37717/21002029	2001 $425,401 USA
University of Geneva Ariel Ruiz i Altaba, Ph.D. Targeting glioblastoma stemness https://doi.org/10.37717/220020296	2011 $449,680 Geneva, Switzerland
University of Illinois at Urbana - Champaign David M. Kranz, Ph.D. Engineering high-affinity T cell receptors for treatment of brain cancer https://doi.org/10.37717/220020075	2005 $449,990 USA
University of Michigan - Ann Arbor Sean Morrison, Ph.D. The role of bmi-1 in neural stem cell self-renewal and neoplastic proliferation	2003 $150,000 USA
University of Michigan - Ann Arbor Sean Morrison, Ph.D. The Role of bmi-1 in Neural Stem Cell Self-Renewal and Neoplastic Proliferation	2004 $297,432 USA
University of North Carolina at Chapel Hill Yue Xiong, Ph.D. Mechanism and Mouse Model for IDHI-Mediated Suppression of Human Secondary Glioblastomas https://doi.org/10.37717/220020203	2009 $449,732 USA
University of Pittsburgh William H. Chambers, Ph.D. RICS Therapy for Gliomas https://doi.org/10.37717/21002041	2001 $449,262 USA
University of Pittsburgh Bo Hu, Ph.D. Mechanisms and inhibition of anti-angiogenic therapy-induced glioma invasion https://doi.org/10.37717/220020244	2010 $450,000 USA
University of Pittsburgh Cancer Institute Shi-Yuan Cheng Interactions and Distinct Roles of Angiogenic Factors in Human Glioma Angiogenesis https://doi.org/10.37717/99-52	1999 $439,364 USA
University of Pittsburgh Medical Center Hideho Okada, M.D., Ph.D. Identification and characterization of glioma-CTL epitopes https://doi.org/10.37717/220020036	2003 $450,000 USA
University of Rochester Steven A. Goldman, M.D., Ph.D. Promoter-based isolation and assessment of differential gene expression by stage-defined glial tumor stem cells https://doi.org/10.37717/220020110	2006 $440,688 USA
University of Texas M.D. Anderson Cancer Center Kenneth D. Aldape, M.D. This grant awarded under The Brain Tumor Funders' Collaborative (BTFC) 2009 RFP. A combined molecular and clinical predictor of progression vs. pseudoprogression in newly diagnosed GBM	2009 $100,000 USA
University of Texas M.D. Anderson Cancer Center Daniel P. Cahill, M.D., Ph.D. Molecular predictors of the mechanism of chemotherapy failure in malignant gliomas https://doi.org/10.37717/220020249	2010 $100,000 USA
University of Texas M.D. Anderson Cancer Center Zhimin Lu, M.D., Ph.D. Regulation of PKM2 in glioblastoma Development https://doi.org/10.37717/220020318	2012 $450,000 USA
University of Texas M.D. Anderson Cancer Center Wei Zhang, Ph.D. Control of glioma cell migration by IIp45 and HDAC6 https://doi.org/10.37717/220020181	2008 $450,000 USA
University of Texas Southwestern Medical Center Luis F. Parada, Ph.D. Large-scale screening for therapeutic targets in a mouse model of glioma. https://doi.org/10.37717/220020206	2009 $90,000 USA
University of Washington Kristin R. Swanson, Ph.D. Dynamics of glioma growth and invasion https://doi.org/10.37717/220020073	2005 $119,030 USA
University of Washington Kristin R. Swanson, Ph.D. Dynamics of brain tumor growth and invasion	2006 $330,970 USA
University of Washington Kristin R. Swanson, Ph.D. Co-Principal Investigators: Alexander Anderson (Moffitt Cancer Center), Peter Canoll (Columbia University) Predicting and controlling glioma recurrence: The role of heterogeneity and microenvironment	2011 USA
Uppsala University Monica Nistér Generation of a YAC transgenic mouse model to study the role of PDGFRA in brain tumor development https://doi.org/10.37717/9900002	1999 $336,000 Sweden
Vanderbilt University Medical Center H. Alex Brown, Ph.D. Novel lipid targets in the treatment of human glioblastomas	2010 $150,000 USA
Vanderbilt University Medical Center H. Alex Brown, Ph.D. Novel lipid targets in the treatment of human glioblastomas	2011 $300,000 USA
Vanderbilt University Medical Center Anna Marie Kenney, Ph.D. Co-Investigator: Zaher Nahle, Ph.D. Vanderbilt University Medical Center Hedgehog and hippo signaling as drivers of medulloblastoma and cell division-associated metabolic choices https://doi.org/10.37717/220020248	2010 $450,000 USA
Virginia Commonwealth University Oliver Bogler, Ph.D. Investigating the Biological Function of the Glioma Associated Gene SETA	1998 $395,296 USA
Virginia Commonwealth University Devanand Sarkar, Ph.D. Analyzing the role of Astrocyte Elevated Gene-1 (AEG-1) in malignant glioma https://doi.org/10.37717/220020251	2010 $450,000 USA
Washington University in St. Louis David H. Gutmann, M.D., Ph.D. Development of preclinical mouse models of meningioma https://doi.org/10.37717/220020051	2003 $150,000 USA
Washington University in St. Louis David H. Gutmann, M.D., Ph.D. Development of preclinical mouse models of meningioma	2004 $300,000 USA
Yale University Frank J. Slack, Ph.D. MicroRNAs in brain cancer https://doi.org/10.37717/220020111	2006 $430,821 USA